March to May is usually the most popular time to visit Mexico City, especially if you’re focused on city stays, food, and design. Outside that window, weather, crowds, and prices can change—so the neighborhood you pick matters more.
If your dates are fixed, choose between Roma / Condesa and Centro Histórico first, then decide whether design apartments or a more spacious stay fits your days better.
If your dates are flexible, shifting a week or two around March to May can mean easier availability and a less crowded feel.
Polanco is useful when Roma / Condesa feels too busy or when you want a different balance of price, quiet, and access.
Pack a little buffer into your arrival day in Mexico City so the first night is about settling in, not racing across town.